17 Headline-Making Moments on The Oprah Show

Dr. William Petit—2010

In December 2010, Oprah sat down for the first interview with Dr. William Petit, the victim of an unspeakable crime. His life was shattered when home invaders murdered his wife and two daughters and burned his home.

"I went to sleep one night in a nice home with a loving family and basically awakened in an emergency room naked on a gurney with no clothes, no family, no home," Dr. Petit told Oprah. "Everything was gone."