García Márquez has said that being forced into the margins has prompted Latin America, in no small way, to respond with life, persisting through every oppression—war, catastrophe, famine. There's something very optimistic about this observation. It suggests that resistance to solitude is the life-affirming solution to exile, even in the hardest of times.
Optimism was García Márquez's goal, ultimately. He joined Faulkner—one of his greatest influences—in saying, "I decline to accept the end of man" (which was a part of Faulkner's Nobel Prize speech). Despite the grave messages of One Hundred Years of Solitude, García Márquez doesn't give up all hope in society or people. It seems that in some ways, he wrote this novel as an act of faith in the idea that the world might eventually give the voiceless and the solitary a second chance. More than anything, he must have wished to motivate people out of their own self-exile, out of solitude, as a way to share in the greatest human story of all.