- Describing his own conception, Cal writes: "The timing of the thing had to be just so in order for me to become the person I am. Delay the act by an hour and you change the gene selection" (p. 11). Is Cal's condition a result of chance or of fate? Which of these forces governs the world as Cal sees it?
- When Tessie and Milton decide to try to influence the sex of their baby, Desdemona disapproves. "God decides what baby is," she says. "Not you" (p. 13). What happens when characters in the novel challenge fate?
- "All I know is this: despite my androgenized brain, there's an innate feminine circularity in the story I have to tell" (p. 20). What does Cal mean by this? Is his manner of telling his story connected to the question of his gender? How?
- Calliope is the name of the classical Greek muse of eloquence and epic poetry. What elements of Greek mythology figure into Cal's story? Is this novel meant to be a new "myth"?
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