As the head of a city known for its free spirit, San Francisco Mayor Gavin Newsom's policies, such as allowing the city-county clerk to issue marriage licenses to same-sex couples, has helped him win the past two mayoral elections. Gayle talks with Mayor Newsom at O, The Oprah Magazine 's annual O You! Conference, held this year in San Francisco, about his political career and what he is doing to make his city a national leader.

See pictures from the O You! conference.


More From the O You! Conference

• Financial Expert Suze Orman
• San Francisco Treats
• Life Coach Martha Beck
• Building a Green Economy