Two big names…two admirable causes. Gayle talks to Bobby Shriver about the (RED)™ campaign, and later welcomes Jon Bon Jovi to talk about his Hurricane Katrina relief efforts!

Gayle talks to Bobby Shriver about his mission to help end the AIDS crisis in Africa. He is spearheading, along with Bono, the (RED) campaign, an economic initiative aimed at raising money for the Global Fund to Fight AIDS, Tuberculosis and Malaria. Retailers such as Gap, Converse and Motorola all created Project (RED) product lines, of which part of the proceeds will be donated to the Global Fund to purchase drugs that can help treat HIV/AIDS in Africa. "To me, this is the biggest healthcare crisis in the history of the world," Bobby tells Gayle.

How was the concept developed? "We kept telling people that 6,000 Africans dying every day—who if they had a pill would live—was an emergency, and then everybody would nod their head at us and then they didn't act like it was an emergency," Bobby says. "So we thought, we have to come up with something that really conveys what the emergency is. What's the color of an emergency? Red. And it's the color of blood, which is the way HIV is transmitted. We're going to have a brand, and we're going to get these big companies to build that brand with us."

Bobby says the campaign was designed to make it easy for people to want to help. "You're going to get a cell phone anyway—get a (RED) one," he says. "You're going to buy T-shirts or jeans or belts or back-to-school things—buy the (RED) ones!"

Gayle also welcomes Jon Bon Jovi, who just one year ago donated $1 million to Oprah's Angel Network for a new neighborhood in Houma, Louisiana, which was devastated by Hurricane Katrina. Since then, he has gone down to the Gulf Coast to help build dozens of homes.

"I was so humbled," Jon says. "You see peoples' lives devastated in such a manner…I can't tell you how powerful an impression it made on me. Because you donate money sometimes and you wonder if it's done any good but when you go down…and give the keys to the families and you hear their stories and you share the memory with them and you know that they relied on the kindness of strangers to get them through—it was one of the most rewarding moments of my life."