Photo: Cliff Watts
Oprah has been answering this question since her very first O, The Oprah Magazine column in May 2000. But we want to hear your thoughts—what are your guiding truths? What message gets you through the day? As Oprah says, the power of the question is the power of sharing its answers.
Tell us in the comments below!
From the November 2008 issue of O, The Oprah Magazine
We Hear You!