"After 18 years on the air, I thought I had done it all," says Oprah. "Then came a once-in-a-lifetime opportunity I couldn't resist. I was given the chance to travel 400 years back in time. I didn't have a clue what I was in for!"
Oprah and Gayle's trip began with a cross-country flight to the very tip of Maine, followed by a four-hour car ride to the "colony." There, they traded high heels for boots and bonnets... and the adventure began.
Browse the gallery for Oprah's thoughts and exclusive photographs!