Saying yes to every assignment and every request, no matter how tough, is what gets many working women big promotions and raises. But is it possible to stand up and say no without hurting your career? O, The Oprah Magazine contributor and working mother Suzy Welch talks with Jean about her article "Can You Work This Weekend?" in the March 2008 issue, which takes a closer look at how to turn things down without ruining your career.