If your young ones aren't so young anymore, consider sending their favorite childhood DVDs to Kid Flicks, an organization run by four sisters whose goal is a library of family-friendly movies for every children's hospital and pediatric department in the country.
The Get-Well Gamers Foundation believes that playing Madden NFL 13 can help hospitalized children forget their pain. Send new and used games to its California headquarters. Have older games or an outdated gaming system? Donate Games also accepts used games and systems—including your 1990s Mario Kart—and then posts them for sale at a discounted price. Purchases fund medical research to help fight rare, life-threatening or debilitating diseases.