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Points of Interest
These days it's standard for a GPS device to have pre-loaded maps of the United States and all its roadways, a computerized voice that guides you and additional stuff like finding hotels, restaurants, gas stations, banks and local attractions (often called "points of interest" or "POIs"). It's simply a matter of typing in an address and following the audio cues and map.
Other things to consider include real-time traffic information, the ability to use your GPS device as a speakerphone, and storage for digital music or audio books.