While speaking with Randy in Virginia, Dr. Oz says he suggested they take a break and toss around a football. So Randy went and got one—but it was no ordinary ball. The day before, he had worked out with the Pittsburgh Steelers and had the entire team sign a ball…and now he was going to use that prized ball to play catch!

"I said, 'We can't have a catch with this, it's signed,'" Dr. Oz says. "He said, 'What am I going to do with it?' We ought to all be living our lives like that. What's the point of saving it? We might as well enjoy it."

Oprah mentions a quote by Leonardo da Vinci: "As a well spent day brings happy sleep, so life well used brings happy death." Does Randy think his life was "well used"?

"I'm married to an incredible woman, and I have great kids, and it's hard for me to imagine," he says. "I like to think that I have helped a lot of other people—and that's the best definition I know of time well spent."

Watch families inspired by Randy Pausch's lecture.  

Sadly, Randy passed away on July 25, 2008. Listen to how his story touched Dr. Oz.