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Few people get worked up over the occasional bruise. We know from experience that a purplish spot isn't usually cause for alarm and, in time, will clear up on its own—a classic case of the wait-and-see approach making sound medical sense. But other discolorations that may appear harmless can serve as warning signals for serious diseases, like diabetes, skin cancer, and autoimmune disorders. The sooner you pick up on the clues, the faster you can take the right steps to getting and staying healthier.