The FDA has not yet approved any oral drugs for sweating, says Pariser. However, you can talk to your doctor about off-label uses of medications like anticholinergics, which work by blocking the transmission of acetylcholine, the chemical messenger responsible for excessive sweating. Pariser says that anticholinergics have been used in the past to treat stomach ulcers (by decreasing acid) and overactive bladders (by decreasing urinary fluids). When used to treat hyperhidrosis, they usually cause uncomfortable dryness in bodily orifices such as the mouth, eyes and vagina.
One more thing: These drugs aren't meant to be a long-term solution, and are best suited for serious sweaters (think Albert Brooks in Broadcast News) who have tried everything else.
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