Men: Often the first sign of heart disease is a heart attack itself, a feeling like the chest is being run over by a Mack truck.

Women: Women’s first warning signs are much more subtle and often hard to pinpoint. They may feel fatigue when doing something that they used to do easily, such as play tennis, run to catch a train, change sheets, or walk up two flights of stairs. Sometimes heart disease registers in women as a feeling of mild indigestion. Often there’s no chest pain whatsoever.