Excerpt from The Female Brain
Most of the time, a girl like Emma would be the one in ten who is simply a tomboy. In this case, Emma had CAH. Congenital adrenal hyperplasia causes fetuses to produce large amounts of testosterone, the sex and aggression hormone, from their adrenal glands starting at about eight weeks after conception—the very moment their brains begin to take shape into the male or female design. If we look at genetic females whose brains are exposed to surges of testosterone during this period, we see that these girls' behavior and presumably brain structures are more similar to those of males than to those of females. I say "presumably" because a toddler's brain isn't so easy to study. Can you imagine a two-year-old sitting still for a couple of hours in an MRI scanner without being sedated? But we can deduce a lot from behavior.
The study of congenital adrenal hyperplasia provides evidence that testosterone erodes the normally robust brain structures in girls. At one year old, CAH girls make measurably less eye contact than other girls the same age. As these testosterone-exposed girls get older, they are far more inclined to scuffling, roughhousing, and fantasy play about monsters or action heroes than to pretending to take care of their dolls or dressing up in princess costumes. They also do better than other girls on spatial tests, scoring similarly to boys, while they do less well on tests that tap verbal behavior, empathy, nurturing, and intimacy—traits that are typically female. The implications are that the male and female brains' wiring for social connection is significantly affected not just by genes but by the amount of testosterone that gets into the fetal brain. Lynn was relieved to have a scientific reason for some of her daughter's behaviors, since no one had taken the time to explain to her what happens in the CAH brain.