Though he'll still join Oprah in Chicago from time to time, he's packing up his medical bag and heading to New York City to host his own show, The Dr. Oz Show !
Dr. Oz says he still remembers the first time he got a call from Oprah's producers.
"I wasn't really clear on this Oprah phenomenon," he says. "[I knew] everyone learned from it, and I remember grabbing a clean pair of scrubs. … I hopped on the plane, and I came to Chicago."
Oprah says Dr. Oz's impact on viewers' health has been huge. "He has taught us how our bodies work, how to get healthier, how to live longer," she says. "And he's made medical mumbo jumbo that [doctors] sometimes speak make sense to us."
Over the years, viewers began to trust Dr. Oz so much, no medical questions were off-limits…even ones that dealt with the most personal, embarrassing topics.
Oprah says she'll never forget Maureen, a mom who told Dr. Oz that she suffered from diarrhea, constipation and hemorrhoids. When she did have a bowel movement, she said her stool looked like tiny marbles. At the time, Dr. Oz said a person's poop should ideally be S-shaped .
What happens after you make an embarrassing admission on national TV? As soon as she got home, Maureen says people started calling. "They were saying, ''Oh, I have a similar problem. I can't believe it.' or ''What's your poop like now?'" she says. "I have to admit, I don't know if I ever got the S. I think my tiny marbles changed to kind of like a banana. I'm like the Chiquita girl now."
Oprah takes a moment to thank Maureen for asking the question no one else wanted to ask.
"I think the poop question really changed our relationship, Dr. Oz and I," she says. "You opened the door to really a greater sensitivity between the two of us."
After talking about poop on television, she says she realized nothing was off-limits with Dr. Oz. "Nobody likes to talk about it," she says. "Everybody's embarrassed right now, but just think, everybody you're going to see today…they poop."
Another memorable admission came from Marcy , a woman who told Dr. Oz and Oprah about her special talent. "When I have sex, I can have multiple orgasms," she said. "Eight to 18."
Now, Marcy admits that she was incredibly nervous the morning of the taping. "Your producer, Anne, helped me so much. She even located some Pepto-Bismol for me," she says. "But I got through it."
After the show aired, reactions started pouring in. That night, Marcy says got a phone call from her best friend in Texas. "She said, ''I cannot believe you asked that question on TV!'" she says.
Scott, Marcy's husband, also got quite a reaction. "I got a lot of slack at work," he says. "They'd pull me aside and say, ''What's your secret?' Of course it's nothing I'm doing. That's her gift."
Now that her secret's out, Marcy knows she's not the only lucky one. "My friend from Texas actually can do it. Lots of my family members can do it," she says. "So I'm not alone. I thought I was, but obviously, I'm not."
Who can forget Michele, the woman who asked Dr. Oz if she could be allergic to her husband's sperm?
After opening up on TV, Michele says friends and family members started sharing their own medical questions. "I was very surprised that a lot of people had the similar question, and they were afraid to ask it," she says. "It did open up dialogue. It was very important for me, very empowering to actually have asked the question. It opened up my eyes that I need to take my health seriously."
In 2008, Michele started having other health issues. When she went to see a doctor, she says she was very honest about her symptoms. "I ended up having a diagnosis that required brain surgery," she says. "So these shows are very important."
Dr. Oz says it's important to get patients comfortable enough to ask their physicians these embarrassing, awkward questions. "I'm very proud that you were honest enough to ask me these questions," he says.
Sometimes, a simple question or second opinion can lead to a lifesaving diagnosis. Over the years, Dr. Oz has offered advice on everything from heart disease to colon cancer . Little does he know, some of these segments helped save lives.
Hundreds of viewers have written in to say that something Dr. Oz said changed the course of their lives.
After undergoing a double mastectomy to remove cancerous tissue, Catherine says she was at home recovering when she saw Dr. Oz's discussion of medical mistakes . "You said these words that really stuck with me—that you are in charge of your own body and you are the world's expert on your own body," she says. "I remember thinking I was so lucky that my surgery had gone well."
The next day, Catherine went in for a follow-up appointment. Her surgeon removed the drains from her chest, and then, she says she reached up to touch the spot where the tumor had been. "The lump was still there," she says. "I had seen the medical mistake show, and every cell in my body was screaming, ''This is the same lump!'"
At Catherine's insistence, doctors did a mammogram and determined it was, in fact, the original tumor. "He had completely missed it," she says.
Now, Catherine says the lump is gone, and she's doing better…thanks to Dr. Oz.
After watching Dr. Oz discuss colon cancer on The Oprah Show, Sandra, a 57-year-old woman from Phoenix, says she scheduled a colonoscopy.
"[My doctor] asked if I was having any symptoms of any kind, any bleeding from the rectum or change in bowel movements, and I hadn't," she says. "So he asked me, ''Why are you coming to have a colonoscopy?' And I told him, ''Because Dr. Oz said so.'"
During the procedure, doctors discovered that Sandra had colon cancer. "They removed a foot of my colon," she says. "I had no chemotherapy, no radiation because they caught it in the first stages."
Brad, a 35-year-old husband and father from Michigan, says he gave up a testicle so his wife could see Oprah…literally.
Brad says he tuned in to see Dr. Oz offer advice to an audience full of men . "You were talking about how to give a self-exam for testicular cancer, and I found a lump," he says. "I procrastinated for a while because, like most guys, it's embarrassing to go to the doctor and ask him to check out your balls. So I waited."
When Brad finally went to see a physician, he found out he had cancer. He says he had surgery on Christmas Eve to remove the lump, and now, he's doing fantastic. "I really wanted to come here, and on behalf of my two little boys at home and my wife, really just to thank you for saving my life," he says to Dr. Oz.
In March 2009, Karan, a 53-year-old mom from New Jersey, got on the treadmill, like she does every morning. Only this time, something was different. "I, all of a sudden, felt horrible," she says. "I had a burning across my chest. I couldn't breathe, so I thought, ''Maybe it's my asthma.'"
Then, Karan says she started having jaw pain, which triggered a memory of something Dr. Oz once said. "I remember from your show that you said [jaw pain] was a symptom of a heart attack ," she says. "So I woke my husband up and said, ''Come on, we've got to go to the hospital.'"
Thankfully, Karan survived to share her story with Dr. Oz. "I have to thank you from the bottom of my damaged heart for giving me my life," she says.
Shay also traveled to Chicago to thank Dr. Oz for saving her life. Shay says she saw a picture of a melanoma during an Oprah Show segment about skin cancer. "I thought to myself, ''That's what my mole looks like on the back of my leg,'" she says.
Days later, a dermatologist removed Shay's mole. "He took the surrounding tissue and called me two days later and said that it was, in fact, melanoma," she says. "I had been married for a year. I had everything to live for, and I was so worried that this was going to take my life."
Doctors soon discovered the cancer had spread to Shay's lymph nodes, which required more surgery. "[They] took all my lymph nodes," she tells Dr. Oz. "I went through immunotherapy for a monthlong period of time, but I would not be here today if it wasn't for you."
Dr. Oz's advice hasn't just saved lives…it's also changed many viewers' quality of life. Thanks to his diet and fitness tips , overweight men and women have been able to transform their bodies and takes charge of their health.
Jillian , a past guest, went from drinking 300 ounces of diet soda a day to jogging 20 miles a week. With Dr. Oz's help, she's also lost 50 pounds.
Weight loss all-star Jason has dropped 70 pounds by walking 30 minutes a day and adding whole grains to his diet. As a result, he cured himself of hypertension, sleep apnea and all signs of diabetes.
Back in 2007, Dr. Oz called Frank a "ticking time bomb." Now, this professional bowler is 103 pounds lighter. He says he's keeping it off by avoiding fried foods and working out daily.
Dr. Oz has worked closely with Jillian, Jason and Frank, but he's never met James, a viewer who's been following Dr. Oz's diet plan for 18 months.
James once weighed 273 pounds, but after adopting a few of Dr. Oz's health tips, he weighs just 158 pounds! "[Dr. Oz] had said, ''The biggest fighter against fat is knowledge,'" he says. "So just by watching his show, I've changed from processed foods to one-ingredient foods." James says Dr. Oz also inspired him to quit smoking.
Sadly, heart attacks have killed all the men in James' family before their 51st birthday, but things are about to change. "My father passed at age 48 of a heart attack, and I don't want to go down that route," he says. "I want to live."
In 2006, Kim weighed in at 332 pounds. Then, she says she was scared skinny by something Dr. Oz said. "I was watching the show one day, and you said that once a person reaches 400 pounds, they rarely have a chance to lose weight," she says.
On that show, Dr. Oz also encouraged overweight people to get out and start walking…so that's exactly what Kim did. "You wanted everyone to walk 30 minutes a day, and I thought, ''I can walk 30 minutes a day,'" she says. "So every morning, rain or shine, I was out in the park behind my house." So far, Kim has lost 164 pounds!
By meeting women like Kim over the years, Dr. Oz says he's also learned something about being a doctor. "The message is the medicine. I didn't have to give you any pills, but you got a little bit of an insight about actual steps that work for you, connected with you emotionally," he says. "I think this is the future of what we're going to do."
Patients aren't the only people who've benefited from Dr. Oz's advice. Doctors and nurses from across the country say they also have something to be grateful for.
"I wanted to say 'thank you to Dr. Oz for helping me take my patient care to a higher level," says Wendy, a cancer nurse of 19 years.
When Dr. Aaron Epstein worked on Wednesdays, he says he could usually guess what Dr. Oz had discussed the previous day on The Oprah Show. But, one day, he was stumped when overweight men started coming in with exercise-related muscle strains and back pains.
"I couldn't figure out why the change of heart all of a sudden," he says. "Then my wife told me that she learned on the Dr. Oz show that week that men who lose 30 pounds of weight gain an inch in their penis size."
No Dr. Oz send-off would be complete without the health aide he helped make a household name—the neti pot !
When Dr. Oz first introduced Americans to this natural remedy for sinus pain and congestion, they flew off drugstore shelves! Now, Oprah says she can't go anywhere without hers.
"I was in South Africa, and I didn't have a neti pot," she says. "I was stuffed up and couldn't breathe, and I went in and I didn't have a neti pot, so I tried to find a gravy dish to try to do it!"
To mark this memorable Dr. Oz moment, everyone in the audience is going home with a neti pot!
Dr. Oz says his success wouldn't have been possible without the support of his family and Dr. Michael Roizen, the research partner he says is like a brother.
"I have enjoyed every moment of everything we have done together. I've learned a ton about how to talk to people," he tells Oprah. "I've become a better doctor, a better father [and], I think, a better human being because I've been able to work with you on these, and I promise you, I will make you proud."
With champagne in hand, Oprah toasts Dr. Oz and wishes him great success. "I'd like for all of us to raise our glasses to an honorable man who has been a great teacher and a great healer," she says. "Bringing us all closer to better health, better wisdom and a better life for ourselves."