Laura Webber and Luke Spencer, General Hospital
Luke and Laura recited their vows in front of more than 30 million viewers, and their 1981 nuptials remain the highest-rated hour in soap opera history. The event featured a cameo from Elizabeth Taylor and even landed the couple on the cover of Newsweek. Luke and Laura were married for two decades and had two kids together. Today, though they're plagued by health problems, they remain two of Port Charles' most memorable residents.