Izzie Stevens and Alex Karev, Grey's Anatomy
The wedding may have been intended for Meredith, but it was destined for Izzie. It had all the bells and whistles of a little girl's dream wedding—not quite right for the low-key MerDer. Weddings are generally weepy, and Grey's is a perpetual tearjerker, so when Shonda Rhimes put them together and added a supposedly dying bride, the hankie factor went through the roof. How Meredith and Izzie fit into the same dress is a question for another time.
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