Rachel McAdams as Regina George in Mean Girls

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Regina George, Mean Girls
As the leader of "the Plastics," Regina is the girl we all feared, and revered, in high school. At her best, your pet name is "loser," and at her worst—well, that's not fit for print. And still, you'd just die to shake your booty to "Jingle Bell Rock" with her or score a spot at her lunch table. We hate her because she's real; we love to hate her because she reminds us that if we can survive the high school jungle, we can make it through anything.