In fall 2009, George's late-night talk show will premiere on TBS. "Mine is different because my couch will be covered in plastic," he jokes. "You won't be able to sit."

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A famous friend is even helping him promote it—President Barack Obama, who filmed a bit for the show. How did he get the president to sign on? "Fortunately for me, you can't get elected in this country without the Latino vote. He needed all seven of them," he jokes. "I was out there campaigning with him and I asked him, and, you know, he's a very nice man."