While this is the first time Oprah will be the principal speaker at Harvard's afternoon exercises, she's no stranger to inspiring college students. Last year, she delivered Spelman College's commencement address. 

Harvard President Drew Faust is looking forward to the address. "Oprah’s journey from her grandmother’s Mississippi farm to becoming one of the world’s most admired women is one of the great American success stories, " he told the Harvard Gazette. “She has used her extraordinary influence and reach as a force for good in the world, with a constant focus on the importance of educational opportunity and the virtues of serving others.”