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Ask Val: Can My Skin Adapt to a Product to the Extent That It Doesn't Work Anymore?
A: Yes. For example, your skin can build up a tolerance for retinoids, the vitamin-A derivatives (and gold-standard wrinkle reducers), like Retin-A, Avage, and Differin; using a greater concentration will improve effectiveness, says Debra Jaliman, MD, author of the forthcoming book Skin Rules: Trade Secrets from a Top New York Dermatologist.
Keep in mind: Increasing exfoliation—by adding an alpha hydroxy acid or a cleansing brush to your regimen—can improve the performance of treatment products.
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