Face the Facts 3 of 6 Needle Pain Without any anesthetic, injections (whether a filler or Botox) can feel like anything from a mosquito bite to a bee sting. Most doctors will apply a topical numbing cream beforehand; collagen fillers are always premixed with an anesthetic to further minimize discomfort. Many doctors will also administer a "nerve block" (a shot similar to the one you get at the dentist) to numb the entire area so you'll hardly even feel a prick. This is almost always done when you're getting a filler in the lips or near the mouth, by far the most sensitive area of the face. A popular plumper… » From Is This Any Way to Treat a Face? in the March 2007 issue of O, The Oprah Magazine. Subscribe now!